Heat Indicators
Keep Track of the Combined Effects of Time and Temperature
Heat exposure degrades the efficacy of many temperature-sensitive medical products, such as vaccines, biologics and biosimilars. Depending on the product, it's performance can degrade immediately when a threshold temperature is reached or gradually with extended exposure to temperature over time.
Zebra offers solutions to support different stability profiles. Apply Zebra HEATmarker® time-temperature indicators to products to monitor heat exposure over time. Apply LIMITmarker® threshold heat indicators to monitor immediate or prolonged exposure at or beyond a threshold temperature. Manufactured by Temptime®, each heat indicator is a miniaturised, self-adhesive temperature monitoring device with a specific profile that determines its response to time and temperature. Changing colour to provide an irreversible visual signal of heat exposure, they reach an endpoint when exposed to the time-temperature limits of its profile, helping you ensure the efficacy of the product for the user.
HEATmarker®

Time-Temperature Indicators
HEATmarker is a miniaturised, self-adhesive temperature monitoring device that can be applied directly to temperature sensitive products. HEATmarker gradually changes colour as heat exposure accumulates. When the gradual colour change surpasses the reference colour the user can identify the product has exceeded its limit.
Industries
- Healthcare
Used for
- Biologics
- Biosimilars
- Pharmaceuticals
- Medical Devices
HEATmarker® VVM

Vaccine Vial Monitors
Used to monitor the temperature exposure of vaccines globally since 1996, identified as a critical component by the World Health Organisation and UNICEF, HEATmarker VVM is an indicator containing a heat-sensitive material that is affixed to a vaccine vial by the manufacturer to allow for full-life heat monitoring.
Industries
- Healthcare
Used for
- Vials
- Syringes
- Ampoules
- Squeezeable tubes
HEATmarker® VVM+

Vaccine Vial Monitors
HEATmarker VVM+ was developed specifically for monitoring heat stable vaccines. HEATmarker VVM+ combines traditional HEATmarker VVM cumulative heat with innovative peak temperature indication technology addressing the risk that vaccines stored outside of the cold chain may be subjected to a peak temperature excursion which could cause rapid degradation.
Industries
- Healthcare
Used for
- Vials
- Syringes
- Ampoules
- Squeezeable tubes
LIMITmarker®

Threshold Heat Indicators
LIMITmarker temperature monitors can be applied directly to heat-sensitive products, available with delayed (2 hrs) or immediate (15 secs) Indication. When exposed to temperatures at or above the response temperature, the heat indicators change colour within a specified response time to give a visual warning.
Industries
- Healthcare
Used for
- Biologics
- Biosimilars
- Pharmaceuticals
- Medical Devices
TransTracker®

Shipment Temperature Indicators
TransTracker indicators with HEATmarker, LIMITmarker or FREEZEmarker temperature sensing indicators are single-use devices that can be placed in shipment packaging to monitor temperature exposures during shipping. TransTracker indicators can be customised with branding and consumer information specific to your use case.
Industries
- Healthcare
Used for
- Medical Devices
- Biologics
- Biosimilars
- Pharmaceuticals
Tools AON Pharmacy Uses to Identify Temperature Excursions
To monitor temperatures during shipment, AON opted for Zebra TransTracker® indicators.
SMP Pharmacy Solutions Delivers Peace of Mind to Patients
LIMITmarker reduced reshipments caused by temperature concerns resulting in improved patient confidence.
Best Practices to Increase Patient Satisfaction and Boost Growth
EncompassRX meets Georgia pharmacy rule enabling patients to easily detect improper storage or temperature variations with LIMITMarker.