Heat Indicators & Time Temperature Indicators | Zebra

Heat Indicators

Boxes of HEATmarker heat indicators

Keep Track of the Combined Effects of Time and Temperature

Heat exposure degrades the efficacy of many temperature-sensitive medical products, such as vaccines, biologics and biosimilars. Depending on the product, it's performance can degrade immediately when a threshold temperature is reached or gradually with extended exposure to temperature over time.

Zebra offers solutions to support different stability profiles. Apply Zebra HEATmarker® time-temperature indicators to products to monitor heat exposure over time. Apply LIMITmarker® threshold heat indicators to monitor immediate or prolonged exposure at or beyond a threshold temperature. Manufactured by Temptime®, each heat indicator is a miniaturised, self-adhesive temperature monitoring device with a specific profile that determines its response to time and temperature. Changing colour to provide an irreversible visual signal of heat exposure, they reach an endpoint when exposed to the time-temperature limits of its profile, helping you ensure the efficacy of the product for the user.

HEATmarker®

Various HEATmarker heat indicator products

Time-Temperature Indicators

HEATmarker is a miniaturised, self-adhesive temperature monitoring device that can be applied directly to temperature sensitive products. HEATmarker gradually changes colour as heat exposure accumulates. When the gradual colour change surpasses the reference colour the user can identify the product has exceeded its limit.

Industries

  • Healthcare

Used for

  • Biologics
  • Biosimilars
  • Pharmaceuticals
  • Medical Devices

HEATmarker® VVM

HEATmarker vaccine vial monitors

Vaccine Vial Monitors

Used to monitor the temperature exposure of vaccines globally since 1996, identified as a critical component by the World Health Organisation and UNICEF, HEATmarker VVM is an indicator containing a heat-sensitive material that is affixed to a vaccine vial by the manufacturer to allow for full-life heat monitoring.

Industries

  • Healthcare

Used for

  • Vials
  • Syringes
  • Ampoules
  • Squeezeable tubes

HEATmarker® VVM+

HEATmarker VVM+ vaccine vial monitor

Vaccine Vial Monitors

HEATmarker VVM+ was developed specifically for monitoring heat stable vaccines. HEATmarker VVM+ combines traditional HEATmarker VVM cumulative heat with innovative peak temperature indication technology addressing the risk that vaccines stored outside of the cold chain may be subjected to a peak temperature excursion which could cause rapid degradation.

Industries

  • Healthcare

Used for

  • Vials
  • Syringes
  • Ampoules
  • Squeezeable tubes

LIMITmarker®

LIMITmarker heat indicator

Threshold Heat Indicators

LIMITmarker temperature monitors can be applied directly to heat-sensitive products, available with delayed (2 hrs) or immediate (15 secs) Indication. When exposed to temperatures at or above the response temperature, the heat indicators change colour within a specified response time to give a visual warning.

Industries

  • Healthcare

Used for

  • Biologics
  • Biosimilars
  • Pharmaceuticals
  • Medical Devices

TransTracker®

TransTracker D heat shipment indicator

Shipment Temperature Indicators

TransTracker indicators with HEATmarker, LIMITmarker or FREEZEmarker temperature sensing indicators are single-use devices that can be placed in shipment packaging to monitor temperature exposures during shipping. TransTracker indicators can be customised with branding and consumer information specific to your use case.

Industries

  • Healthcare

Used for

  • Medical Devices
  • Biologics
  • Biosimilars
  • Pharmaceuticals
TransTracker D heat shipment indicator in use

Tools AON Pharmacy Uses to Identify Temperature Excursions

To monitor temperatures during shipment, AON opted for Zebra TransTracker® indicators.

LIMITmarker heat indicator on box of vaccine vials

SMP Pharmacy Solutions Delivers Peace of Mind to Patients

LIMITmarker reduced reshipments caused by temperature concerns resulting in improved patient confidence.

Best Practices to Increase Patient Satisfaction and Boost Growth

EncompassRX meets Georgia pharmacy rule enabling patients to easily detect improper storage or temperature variations with LIMITMarker.