Irreversible Heat and Reversible 18°C Indicators

Boxes of HEATmarker heat indicators

Visual Indication of Heat Exposure or Room Temperature

Heat exposure can degrade the efficacy of many temperature-sensitive medical products, such as vaccines and biologics.  Even a gradual change in temperature of a product over time can affect the performance. Products such as injectable medications, adhesives and sealants require refrigeration to maintain their efficacy, but are recommended for use at room temperature for optimal performance.

Zebra offers irreversible and reversible indicators that support a variety of different stability profiles, helping you monitor temperature to ensure a positive customer experience. Apply Zebra HEATmarker® time-temperature indicators to monitor heat exposure over time.  Apply LIMITmarker® irreversible threshold heat indicators to monitor immediate or prolonged exposure at or beyond a threshold temperature. Improve the user experience with LIMITmarker Reversible 18⁰C to indicate when an item requiring refrigerated storage approaches room temperature.

HEATmarker®

Various HEATmarker heat indicator products

Time-Temperature Indicators

HEATmarker is a miniaturized, self-adhesive temperature monitoring indicator that can be applied directly to temperature-sensitive products. HEATmarker gradually changes color as heat exposure accumulates. When the gradual color change surpasses the reference color the user can identify if the product has exceeded its temperature limit.

Industries

  • Healthcare

Used for

  • Biologics
  • Biosimilars
  • Pharmaceuticals
  • Medical Devices

HEATmarker® VVM

HEATmarker vaccine vial monitors

Vaccine Vial Monitors

Used to monitor the temperature exposure of vaccines globally since 1996, identified as a critical component by the World Health Organization and UNICEF, HEATmarker VVM is an indicator containing a heat-sensitive material that is affixed to a vaccine vial by the manufacturer to allow for full-life monitoring.

Industries

  • Healthcare

Used for

  • Vials
  • Syringes
  • Ampoules
  • Squeezeable tubes

HEATmarker® VVM+

HEATmarker VVM+ vaccine vial monitor

Vaccine Vial Monitors

HEATmarker VVM+ was developed specifically for monitoring heat stable vaccines. HEATmarker VVM+ combines traditional HEATmarker VVM cumulative heat with innovative peak temperature indication technology addressing the risk that vaccines stored outside of the cold chain may be subjected to a peak temperature excursion which could cause rapid degradation.

Industries

  • Healthcare

Used for

  • Vials
  • Syringes
  • Ampoules
  • Squeezeable tubes

LIMITmarker®

LIMITmarker heat indicator

Threshold Heat Indicators

LIMITmarker irreversible temperature indicators can be applied directly to heat-sensitive products, available with delayed (2 hrs) or immediate (15 secs) Indication. When exposed to temperatures at or above the response temperature, the heat indicators change color within a specified response time to give a visual warning.

Industries

  • Healthcare

Used for

  • Biologics
  • Biosimilars
  • Pharmaceuticals
  • Medical Devices

LIMITmarker® Reversible 18⁰C

LIMITmarker® Reversible 18⁰C label

Reversible Room Temperature Indicators

LIMITmarker Reversible 18⁰C indicators can be applied to the primary packaging of products, providing a clear visual sign when a refrigerated product becomes warm enough to use. The indicator is sold blue when cold (at or below 8⁰C), then changes color and reveals an "OK" message when it approaches room temperature (18⁰C +/- 2⁰C).

Industries

  • Manufacturing

Used for

  • Injectable medication
  • Adhesives
  • Sealants
  • Solvents
  • Some Collagens

TransTracker®

TransTracker D heat shipment indicator

Shipment Temperature Indicators

TransTracker can contain multiple indicators on one card. Choose from HEATmarker, LIMITmarker or FREEZEmarker temperature sensing indicators. These single-use indicators can be placed in shipment packaging to monitor temperature exposures during shipping. TransTracker indicators can be customized with branding and consumer information specific to your use case.

Industries

  • Healthcare

Used for

  • Medical Devices
  • Biologics
  • Biosimilars
  • Pharmaceuticals
TransTracker D heat shipment indicator in use

Tools AON Pharmacy Uses to Identify Temperature Excursions

To monitor temperatures during shipment, AON opted for Zebra’s TransTracker® indicators.

LIMITmarker heat indicator on box of vaccine vials

SMP Pharmacy Solutions Delivers Peace of Mind to Patients

LIMITmarker reduced reshipments caused by temperature concerns resulting in improved patient confidence.

Best Practices to Increase Patient Satisfaction and Boost Growth

EncompassRX meets Georgia pharmacy rule enabling patients to easily detect improper storage or temperature variations with LIMITMarker.