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Ready-To-Use Indicators
HEATmarker VVM
Since 1996, HEATmarker® Vaccine Vial Monitors (VVM), manufactured by Temptime®, have been used to monitor the temperature exposure of vaccines, as recommended by the WHO and UNICEF. In 2012, WHO determined VVM to be a "critical characteristic", a required element of all vaccine tenders submitted to UNICEF.
Monitor the Cumulative Temperature Exposure of Vaccines
HEATmarker VVM and VVM+ indicators are affixed to a vaccine vial by the manufacturer to allow for full-life temperature monitoring. The inner square features a heat-sensitive material that becomes darker when exposed to heat. The color change is faster at higher temperatures and slower at lower temperatures. At the end point, the inner square is the same color as or darker than the outer circle. This allows the HEATmarker VVM to give health workers an overview of the cumulative heat exposure of the vaccine and a clear visual indication when it has reached its time-temperature end point, informing them whether the vaccine should be administered.
Simple Identification of Cumulative Heat Exposure
Simple Identification of Cumulative Heat Exposure
HEATmarker VVM’s inner square features a heat-sensitive chemistry that shows a gradual and permanent color change. Initially light in color, it becomes darker when exposed to heat. At the end point, the inner square is the same color as, or darker than the outer circle. This visual indication alerts healthcare workers of the heat exposure of each vaccine vial to inform them whether the vaccine should be administered.
Preserve Valuable Inventory
Preserve Valuable Inventory
Since their appearance changes gradually over time, health workers can use HEATmarker VVM to easily monitor heat exposure and dispose of only the vaccine inventory that has reached their temperature endpoints. In addition, they can prioritize the use of those vaccines that have had more heat exposure (without exceeding the limit) over those that have not.
Extend Vaccinations to the Last Mile
Extend Vaccinations to the Last Mile
The color change of HEATmarker VVM provides a visible and reliable indicator allowing healthcare professionals to confidently carry vaccines to previously unreachable populations.
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- HEATmarker VVM 250
- HEATmarker VVM 30
- HEATmarker VVM 14
- HEATmarker VVM 11
- HEATmarker VVM 7
- HEATmarker VVM 2
HEATmarker VVM 250
HEATmarker VVM 250 is optimal for use with very high stability vaccines, as defined by WHO/PQS/E006/IN05.3. It features a maximun time to end-point of 250 days at 37°C. Shelf life is 5 years.
HEATmarker VVM 30
HEATmarker VVM 30 is optimal for use with high stability vaccines, as defined by WHO/PQS/E006/IN05.3. It features a maximun time to end-point of 30 days at 37°C. Shelf life is 5 years.
HEATmarker VVM 14
HEATmarker VVM 14 is optimal for use with medium stability vaccines, as defined by WHO/PQS/E006/IN05.3. It features a maximun time to end-point of 14 days at 37°C. Shelf life is 5 years.
HEATmarker VVM 11
HEATmarker VVM 11 is optimal for use with intermediate stability vaccines, as defined by WHO/PQS/E006/IN05.3. It features a maximun time to end-point of 11 days at 37°C. Shelf life is 4 years.
HEATmarker VVM 7
HEATmarker VVM 7 is optimal for use with moderate stability vaccines, as defined by WHO/PQS/E006/IN05.3. It features a maximun time to end-point of 7 days at 37°C. Shelf life is 4 years.
HEATmarker VVM 2
HEATmarker VVM 2 is optimal for use with vaccines with the least stability, as defined by WHO/PQS/E006/IN05.3. It features a maximun time to end-point of 2 days at 37°C. Shelf life is 4 years.
Additional Resources
| HEATmarker VVM Fact Sheet R2, Doc #3189 | Download Fact Sheet Download Fact Sheet | |
|---|---|---|
| WHO/PQS/E006/IN05.4 Compliance | Learn More Learn More | |
| WHO Testing Protocol | Learn More Learn More | |
| WHO-UNICEF VVM Policy Statement | Learn More Learn More | |
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